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dc.contributor.authorDoroshenko, A.en
dc.contributor.authorChernov, Vladimir Ivanovichen
dc.contributor.authorMedvedeva, Anna Aleksndrovnaen
dc.contributor.authorZelchan, Roman Vladimirovichen
dc.contributor.authorSlonimskaya, E.en
dc.contributor.authorVarlamova, Natalya Valeryevnaen
dc.contributor.authorSkuridin, Viktor Sergeyevichen
dc.contributor.authorDergilev, A.en
dc.contributor.authorSinilkin, Ivan Gennadjevichen
dc.date.accessioned2016-11-30T17:27:43Z-
dc.date.available2016-11-30T17:27:43Z-
dc.date.issued2016-
dc.identifier.citationThe first experience of using of {99}mTc-Al[2]O[3] for detection of sentinel lymph nodes in breast cancer / A. Doroshenko [et al.] // IOP Conference Series: Materials Science and Engineering. — 2016. — Vol. 135 : Issues of Physics and Technology in Science, Industry and Medicine : VIII International Scientific Conference, 1–3 June 2016, Tomsk, Russia : [proceedings]. — [012011, 5 p.].ru
dc.identifier.urihttp://earchive.tpu.ru/handle/11683/34799-
dc.description.abstractPurpose: to study the feasibility of using the new radiopharmaceutical based on the technetium-99m-labeled gamma-alumina for identification of sentinel lymph nodes (SLNs) in breast cancer patients. Materials and methods. The study included two groups of breast cancer patients who underwent single photon emission computed tomography (SPECT) and intraoperaive gamma probe identification of sentinel lymph nodes (SLNs). To identify SLNs, the day before surgery Group I patients (n=34) were injected with radioactive {99m}Tc-Al[2]0[3], and Group II patients (n=30) received {99m}Tc-labeled phytate colloid. Results. A total of 37 SLNs were detected in Group I patients. The number of identified SLNs per patient ranged from 1 to 2 (the average number of identified SLNs was 1.08). Axillary lymph nodes were the most common site of SLN localization. At 18 hours after {99m}Tc-Al[2]0[3] injection, the percentage of its accumulation in the SLN was 7-11% (of the counts in the injection site) by SPECT and 17-31% by gamma probe detection. In Group II patients, SLNs were detected in 27 patients. At 18 hours after injection of the phytate colloid, the percentage of its accumulation in the SLN was 1.5-2% out of the counts in the injection site by SPECT and 4-7% by gamma probe. Conclusion. The new radiopharmaceutical based on the {99m}Tc -Al[2]0[3] demonstrates high accumulation in SLNs without redistribution through the entire lymphatic basin. Sensitivity and specificity of {99m}Tc -Al[2]0[3] were 100% for both SPECT and intraoperative gamma probe identification.en
dc.language.isoenen
dc.publisherIOP Publishingru
dc.relation.ispartofIOP Conference Series: Materials Science and Engineering. Vol. 135 : Issues of Physics and Technology in Science, Industry and Medicine. — Bristol, 2016.ru
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectлимфатические узлыru
dc.subjectракru
dc.subjectрадиофармпрепаратыru
dc.subjectкомпьютерная томографияru
dc.subjectрадиоактивные изотопыru
dc.titleThe first experience of using of {99}mTc-Al[2]O[3] for detection of sentinel lymph nodes in breast canceren
dc.typeConference Paperen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.typeinfo:eu-repo/semantics/conferencePaperen
dcterms.audienceResearchesen
local.departmentНациональный исследовательский Томский политехнический университет (ТПУ)::Физико-технический институт (ФТИ)::Лаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР)ru
local.description.firstpage12011-
local.filepathhttp://dx.doi.org/10.1088/1757-899X/135/1/012011-
local.identifier.bibrecRU\TPU\network\15476-
local.identifier.colkeyRU\TPU\col\20054-
local.identifier.perskeyRU\TPU\pers\34191-
local.identifier.perskeyRU\TPU\pers\37376-
local.identifier.perskeyRU\TPU\pers\34194-
local.identifier.perskeyRU\TPU\pers\32659-
local.identifier.perskeyRU\TPU\pers\32655-
local.identifier.perskeyRU\TPU\pers\34189-
local.localtypeДокладru
local.volume135-
local.conference.nameIssues of Physics and Technology in Science, Industry and Medicine-
local.conference.date2016-
dc.identifier.doi10.1088/1757-899X/135/1/012011-
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