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dc.contributor.authorZeltchan, R.en
dc.contributor.authorMedvedeva, Anna Aleksndrovnaen
dc.contributor.authorSinilkin, Ivan Gennadjevichen
dc.contributor.authorBragina, Olga Dmitrievnaen
dc.contributor.authorChernov, Vladimir Ivanovichen
dc.contributor.authorStasyuk (Stasiuk), Elena Sergeyevnaen
dc.contributor.authorRogov, Alexander Sergeyevichen
dc.contributor.authorLarionova, Lyudmila Aleksandrovnaen
dc.contributor.authorSkuridin, Viktor Sergeyevichen
dc.contributor.authorDergilev, A.en
dc.contributor.authorIlyina, Ekaterina Alekseevnaen
dc.date.accessioned2016-11-30T17:28:04Z-
dc.date.available2016-11-30T17:28:04Z-
dc.date.issued2016-
dc.identifier.citationExperimental study of radiopharmaceuticals based on technetium-99m labeled derivative of glucose for tumor diagnosis / R. Zeltchan [et al.] // IOP Conference Series: Materials Science and Engineering. — 2016. — Vol. 135 : Issues of Physics and Technology in Science, Industry and Medicine : VIII International Scientific Conference, 1–3 June 2016, Tomsk, Russia : [proceedings]. — [012054, 4 p.].ru
dc.identifier.urihttp://earchive.tpu.ru/handle/11683/34845-
dc.description.abstractPurpose: to study the potential utility of 1-thio-D-glucose labeled with 99mTc for cancer imaging in laboratory animals. Materials and method: the study was carried out in cell cultures of normal CHO (Chinese hamster ovary cells CHO) and malignant tissues MCF-7 (human breast adenocarcinoma MCF-7). To evaluate the uptake of 99mTc-1-thio-D-glucose in normal and tumor tissue cells, 25 MBq of 1-thio-D-glucose labeled with 99mTc was added to the vials with 3 million cells and incubated for 30 minutes at room temperature. After centrifugation of the vials with cells, the supernatant was removed. Radioactivity in vials with normal and tumor cells was then measured. In addition, the study included 40 mice of C57B 1/6j lines with tumor lesion of the right femur. For neoplastic lesions, Lewis lung carcinoma model was used. Following anesthesia, mice were injected intravenously with 25MBq of 99mTc-1-thio-D-glucose. Planar scintigraphy was performed 15 minutes later in a matrix of 512x512 pixels for 5 minutes. Results: when measuring the radioactivity of normal and malignant cells after incubation with 99mTc-1-thio-D- glucose, it was found that the radioactivity of malignant cells was higher than that of normal cells. The mean values of radioactivity levels in normal and malignant cells were 0.3±0.15MBq and 1.07±0.6MBq, respectively. All examined animals had increased accumulation of 99mTc-1-thio- D-glucose at the tumor site. The accumulation of 99mTc-1-thio-D-glucose in the tumor was on average twice as high as compared to the symmetric region. Conclusion: The present study demonstrated that 99mTc-1-thio-D-glucose is a prospective radiopharmaceutical for cancer visualization. In addition, high accumulation of 99mTc-1-thio-D-glucose in the culture of cancer cells and in tumor tissue of animals demonstrates tumor tropism of the radiopharmaceutical.en
dc.language.isoenen
dc.publisherIOP Publishingru
dc.relation.ispartofIOP Conference Series: Materials Science and Engineering. Vol. 135 : Issues of Physics and Technology in Science, Industry and Medicine. — Bristol, 2016.ru
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectэкспериментальные исследованияru
dc.subjectрадиофармпрепаратыru
dc.subjectтехнеций-99мru
dc.subjectдиагностикаru
dc.subjectопухолиru
dc.subjectглюкозаru
dc.subjectядерная медицинаru
dc.subjectвизуализацияru
dc.titleExperimental study of radiopharmaceuticals based on technetium-99m labeled derivative of glucose for tumor diagnosisen
dc.typeConference Paperen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.typeinfo:eu-repo/semantics/conferencePaperen
dcterms.audienceResearchesen
local.departmentНациональный исследовательский Томский политехнический университет (ТПУ)::Физико-технический институт (ФТИ)::Лаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР)ru
local.description.firstpage12054-
local.filepathhttp://dx.doi.org/10.1088/1757-899X/135/1/012054-
local.identifier.bibrecRU\TPU\network\15561-
local.identifier.colkeyRU\TPU\col\20054-
local.identifier.perskeyRU\TPU\pers\37376-
local.identifier.perskeyRU\TPU\pers\34189-
local.identifier.perskeyRU\TPU\pers\35943-
local.identifier.perskeyRU\TPU\pers\34191-
local.identifier.perskeyRU\TPU\pers\32656-
local.identifier.perskeyRU\TPU\pers\32658-
local.identifier.perskeyRU\TPU\pers\36172-
local.identifier.perskeyRU\TPU\pers\32655-
local.identifier.perskeyRU\TPU\pers\34266-
local.localtypeДокладru
local.volume135-
local.conference.nameIssues of Physics and Technology in Science, Industry and Medicine-
local.conference.date2016-
dc.identifier.doi10.1088/1757-899X/135/1/012054-
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