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Полная запись метаданных
Поле DC | Значение | Язык |
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dc.contributor.author | Chernov, Vladimir Ivanovich | en |
dc.contributor.author | Sinilkin, Ivan Gennadjevich | en |
dc.contributor.author | Zelchan, Roman Vladimirovich | en |
dc.contributor.author | Medvedeva, Anna Aleksndrovna | en |
dc.contributor.author | Lyapunov, A. Yu. | en |
dc.contributor.author | Bragina, Olga Dmitrievna | en |
dc.contributor.author | Varlamova, Natalya Valeryevna | en |
dc.contributor.author | Skuridin, Viktor Sergeyevich | en |
dc.date.accessioned | 2016-12-28T16:45:05Z | - |
dc.date.available | 2016-12-28T16:45:05Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Experimental study of {99m}Tc-aluminum oxide use for sentinel lymph nodes detection / V. I. Chernov [et al.] // AIP Conference Proceedings. — 2016. — Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 : Proceedings of the International conference, 22-25 March 2016, Tomsk, Russia. — [020012, 5 p.]. | ru |
dc.identifier.uri | http://earchive.tpu.ru/handle/11683/35772 | - |
dc.description.abstract | The purpose of the study was a comparative research in the possibility of using the radiopharmaceuticals {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis for visualizing sentinel lymph nodes. The measurement of the sizes of {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. The pharmacokinetics of {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis was researched on 50 white male rats. The possibility of the use of {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. The average dynamic diameter of the sol particle was 52-77 nm for {99m}Tc-Al[2]O[3] and 16.7-24.5 nm for {99m}Tc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node in 1 hour after administration; the average uptake of {99}mTc-Al[2]O[3] was 8.6% in it, and the accumulation of {99m}Tc-Nanocis was significantly lower-1.8% (p < 0.05). In all study points the average uptake of {99m}Tc-Al[2]O[3] in the lymph node was significantly higher than {99m}Tc-Nanocis accumulation. The results of dynamic scintigraphic studies in rats showed that {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis actively accumulated into the lymphatic system. By using {99m}Tc-Al[2]O[3] inguinal lymph node was determined in 5 minutes after injection and clearly visualized in all the animals in the 15th minute, when the accumulation became more than 1% of the administered dose. Further observation indicated that the {99m}Tc-Al[2]O[3] accumulation reached a plateau in a lymph node (average 10.5%) during 2-hour study and then its accumulation remained practically at the same level, slightly increasing to 12% in 24 hours. In case of {99m}Tc-Nanocis inguinal lymph node was visualized in all animals for 15 min when it was accumulated on the average 1.03% of the administered dose. Plateau of {99m}Tc-Nanocis accumulation in the lymph node (average 2.05%) occurred after 2 hours of the study and remained almost on the same level (in average 2.3%) for 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the {99m}Tc-Al[2]O[3]accumulates actively in the lymph nodes several times as compared to the imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes. | en |
dc.language.iso | en | en |
dc.publisher | AIP Publishing | ru |
dc.relation.ispartof | AIP Conference Proceedings. Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016. — New York, 2016. | ru |
dc.rights | info:eu-repo/semantics/openAccess | en |
dc.subject | экспериментальные исследования | ru |
dc.subject | лимфатические узлы | ru |
dc.subject | радиофармпрепараты | ru |
dc.subject | лимфосцинтиграфия | ru |
dc.subject | сцинтиграфия | ru |
dc.title | Experimental study of {99m}Tc-aluminum oxide use for sentinel lymph nodes detection | en |
dc.type | Conference Paper | en |
dc.type | info:eu-repo/semantics/publishedVersion | en |
dc.type | info:eu-repo/semantics/conferencePaper | en |
dcterms.audience | Researches | en |
local.department | Национальный исследовательский Томский политехнический университет (ТПУ)::Физико-технический институт (ФТИ)::Лаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР) | ru |
local.description.firstpage | 20012 | - |
local.filepath | http://dx.doi.org/10.1063/1.4960231 | - |
local.identifier.bibrec | RU\TPU\network\17248 | - |
local.identifier.colkey | RU\TPU\col\20054 | - |
local.identifier.perskey | RU\TPU\pers\34191 | - |
local.identifier.perskey | RU\TPU\pers\34189 | - |
local.identifier.perskey | RU\TPU\pers\34194 | - |
local.identifier.perskey | RU\TPU\pers\37376 | - |
local.identifier.perskey | RU\TPU\pers\35943 | - |
local.identifier.perskey | RU\TPU\pers\32659 | - |
local.identifier.perskey | RU\TPU\pers\32655 | - |
local.localtype | Доклад | ru |
local.volume | 17602016 | - |
local.conference.name | Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 | - |
local.conference.date | 2016 | - |
dc.identifier.doi | 10.1063/1.4960231 | - |
Располагается в коллекциях: | Материалы конференций |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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dx.doi.org-10.1063-1.4960231.pdf | 281,47 kB | Adobe PDF | Просмотреть/Открыть |
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