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Title: Synthesis and Characterization of Electro-Explosive Magnetic Nanoparticles for Biomedical Applications
Authors: Bakina, O. V.
Glazkova, E. A.
Svarovskaya, N. V.
Lerner, Marat Izrailyevich
Korovin, M. S.
Fomenko, A. N.
Keywords: синтез; характеристики; магнитные наночастицы; наночастицы; биомедицинское применение; токсичность; просвечивающая электронная микроскопия; электрический взрыв; рентгенофазовый анализ; термическая десорбция; раковые заболевания; противоопухолевые препараты; противомикробные средства
Issue Date: 2017
Publisher: AIP Publishing
Citation: Synthesis and Characterization of Electro-Explosive Magnetic Nanoparticles for Biomedical Applications / O. V. Bakina [et al.] // AIP Conference Proceedings. — 2017. — Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17) : Proceedings of the International conference, 23–26 May 2017, Tomsk, Russia. — [020004, 4 p.].
Abstract: Nowadays there are new magnetic nanostructures based on bioactive metals with low toxicity and high efficiency for a wide range of biomedical applications including drugs delivery, antimicrobial drugs design, cells' separation and contrasting. For such applications it is necessary to develop highly magnetic particles with less than100 nm in size. In the present study magnetic nanoparticles Fe, Fe[3]O[4] and bimetallic Cu/Fe with the average size of 60- 90 nm have been synthesized by electrical explosion of wire in an oxygen or argon atmosphere. The produced nanoparticles have been characterized with transmission electron microscopy, X-ray phase analysis, and nitrogen thermal desorption. The synthesized particles have shown antibacterial activity to gram-positive (S. aureus, MRSA) and gramnegative (E. coli, P. aeruginosa) bacteria. According to the cytological data Fe, Fe[3]O[4]and Cu/Fe nanoparticles have effectively inhibited viability of cancer cell lines Neuro-2a and J774. The obtained nanoparticles are promising for new antimicrobial drugs and antitumor agents' development
Appears in Collections:Материалы конференций

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