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dc.contributor.authorLarkina, M.en
dc.contributor.authorPodrezova, Ekaterina Vladimirovnaen
dc.contributor.authorBragina, O.en
dc.contributor.authorStasyuk, Elena Sergeyevnaen
dc.contributor.authorYusubov, Mekhman Suleiman-Ogly (Suleimanovich)en
dc.contributor.authorChernov, Vladimir Ivanovichen
dc.contributor.authorZelchan, Roman Vladimirovichen
dc.contributor.authorSkuridin, Viktor Sergeyevichen
dc.contributor.authorBelousov, M.en
dc.contributor.authorDeev, Sergey Mikhaylovichen
dc.date.accessioned2018-03-20T06:35:37Z-
dc.date.available2018-03-20T06:35:37Z-
dc.date.issued2017-
dc.identifier.citationThe Foundations of the Development of Technologies of the Synthesis of Radiopharmaceuticals / M. Larkina [et al.] // AIP Conference Proceedings. — 2017. — Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17) : Proceedings of the International conference, 23–26 May 2017, Tomsk, Russia. — [020043, 3 p.].en
dc.identifier.urihttp://earchive.tpu.ru/handle/11683/46882-
dc.description.abstractThe selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodoaliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.en
dc.language.isoenen
dc.publisherAIP Publishingen
dc.relation.ispartofAIP Conference Proceedings. Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17). — New York, 2017.en
dc.rightsinfo:eu-repo/semantics/openAccessen
dc.subjectсинтезru
dc.subjectрадиофармпрепаратыru
dc.subjectмишениru
dc.subjectядерная медицинаru
dc.subjectрадионуклидыru
dc.subjectтерапияru
dc.titleThe Foundations of the Development of Technologies of the Synthesis of Radiopharmaceuticalsen
dc.typeConference Paperen
dc.typeinfo:eu-repo/semantics/publishedVersionen
dc.typeinfo:eu-repo/semantics/conferencePaperen
dcterms.audienceResearchesen
local.departmentНациональный исследовательский Томский политехнический университет (ТПУ)::Институт природных ресурсов (ИПР)::Кафедра технологии органических веществ и полимерных материалов (ТОВПМ)ru
local.departmentНациональный исследовательский Томский политехнический университет (ТПУ)::Физико-технический институт (ФТИ)::Лаборатория № 31 ядерного реактора (Лаборатория № 31 ЯР)ru
local.description.firstpage20043-
local.filepathhttps://doi.org/10.1063/1.5001622-
local.identifier.bibrecRU\TPU\network\24460-
local.identifier.colkeyRU\TPU\col\18659-
local.identifier.colkeyRU\TPU\col\20054-
local.identifier.perskeyRU\TPU\pers\40301-
local.identifier.perskeyRU\TPU\pers\32656-
local.identifier.perskeyRU\TPU\pers\31833-
local.identifier.perskeyRU\TPU\pers\34191-
local.identifier.perskeyRU\TPU\pers\34194-
local.identifier.perskeyRU\TPU\pers\32655-
local.identifier.perskeyRU\TPU\pers\39299-
local.localtypeДокладru
local.volume188217-
local.conference.namePhysics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA'17)-
local.conference.date2017-
dc.identifier.doi10.1063/1.5001622-
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