Гетерогенность распределения Th2-лимфоцитов и ILC2 в микроокружении морфологически обособленных структур инвазивной карциномы молочной железы и связь с лимфогенным метастазированием

Abstract

Inflammation plays an important role in a tumor disease. Th2 like type of IIR (immunoinflammatory reaction) is associated with an unfavorable course that can be realized by both the adaptive immunity (Th2lymphocytes) and innate immunity (ILC2). Currently, the prognostic significance of TIL (tumor infiltrating lymphocyte) for triple negative and Her2-positive breast cancer (BC) is showed but not for luminal forms. One of the possible reasons is intratumoral morphological heterogeneity of the invasive breast carcinoma of the nonspecific type (IC NST). In this study, we had shown the heterogeneity of Th2-lymphocytes and ILC2 distribution in the microenvironment of various morphologically distinct structures of the IC NST. In addition, it has been shown that lymph nodes metastasis associated with a high frequency of ILC2 in the microenvironment of trabecular structures of IC NST.