Please use this identifier to cite or link to this item: http://earchive.tpu.ru/handle/11683/57820
Title: Ibuprofen controlled release from E-beam treated polycaprolactone electrospun scaffolds
Authors: Rakina, Apollinariya Aleksandrovna
Spiridonova, Tatjyana Igorevna
Kudryavtseva, Valeriya Lvovna
Kolesnik, Iljya Maksimovich
Sazonov, Roman Vladimirovich
Remnev, Gennady Efimovich
Tverdokhlebov, Sergei Ivanovich
Keywords: полимеры; электроспиннинг; лекарства; модификации; электронные пучки
Issue Date: 2018
Publisher: IOP Publishing
Citation: Ibuprofen controlled release from E-beam treated polycaprolactone electrospun scaffolds / A. A. Rakina [et al.] // Journal of Physics: Conference Series. — 2018. — Vol. 1115 : 6th International Congress "Energy Fluxes and Radiation Effects"14th International Conference on Modification of Materials with Particle Beams and Plasma Flows (14th CMM) : [proceedings], 16-22 September 2018, Tomsk, Russian Federation. — [032051, 5 p.].
Abstract: Synthetic biodegradable polymers are considered to be a highly suitable materials for the targeted drug delivery devices creating. Especially promising is the use of the electrospinning technique, which makes it possible to obtain materials with a high surface-to-volume ratio that provides active diffusion of the drug into the body tissues. In order to control the rate of polymer degradation and drug release from polymer scaffolds surface modification techniques are widely used. This study was focused on the investigation of ibuprofen-loaded poly (e-caprolactone) electrospun fibrous scaffolds and modification of theirs surface. Scaffolds with two ibuprofen concentrations were obtained: 5 wt./wt. % and 10 wt./wt.%. The modification was conducted by the pulsed electron beam irradiation. The sustained release of the model drug over a period of one day from both non-treated and treated samples was demonstrated. It was shown, that treatment leads to an increase in drug release rate and does not change surface morphology of scaffolds and fibers diameter distribution.
URI: http://earchive.tpu.ru/handle/11683/57820
Appears in Collections:Материалы конференций

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