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http://earchive.tpu.ru/handle/11683/35772
Название: | Experimental study of {99m}Tc-aluminum oxide use for sentinel lymph nodes detection |
Авторы: | Chernov, Vladimir Ivanovich Sinilkin, Ivan Gennadjevich Zelchan, Roman Vladimirovich Medvedeva, Anna Aleksndrovna Lyapunov, A. Yu. Bragina, Olga Dmitrievna Varlamova, Natalya Valeryevna Skuridin, Viktor Sergeyevich |
Ключевые слова: | экспериментальные исследования; лимфатические узлы; радиофармпрепараты; лимфосцинтиграфия; сцинтиграфия |
Дата публикации: | 2016 |
Издатель: | AIP Publishing |
Библиографическое описание: | Experimental study of {99m}Tc-aluminum oxide use for sentinel lymph nodes detection / V. I. Chernov [et al.] // AIP Conference Proceedings. — 2016. — Vol. 1760 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications 2016 : Proceedings of the International conference, 22-25 March 2016, Tomsk, Russia. — [020012, 5 p.]. |
Аннотация: | The purpose of the study was a comparative research in the possibility of using the radiopharmaceuticals {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis for visualizing sentinel lymph nodes. The measurement of the sizes of {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis colloidal particles was performed in seven series of radiopharmaceuticals. The pharmacokinetics of {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis was researched on 50 white male rats. The possibility of the use of {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis for lymphoscintigraphy was studied in the experiments on 12 white male rats. The average dynamic diameter of the sol particle was 52-77 nm for {99m}Tc-Al[2]O[3] and 16.7-24.5 nm for {99m}Tc-Nanocis. Radiopharmaceuticals accumulated in the inguinal lymph node in 1 hour after administration; the average uptake of {99}mTc-Al[2]O[3] was 8.6% in it, and the accumulation of {99m}Tc-Nanocis was significantly lower-1.8% (p < 0.05). In all study points the average uptake of {99m}Tc-Al[2]O[3] in the lymph node was significantly higher than {99m}Tc-Nanocis accumulation. The results of dynamic scintigraphic studies in rats showed that {99m}Tc-Al[2]O[3] and {99m}Tc-Nanocis actively accumulated into the lymphatic system. By using {99m}Tc-Al[2]O[3] inguinal lymph node was determined in 5 minutes after injection and clearly visualized in all the animals in the 15th minute, when the accumulation became more than 1% of the administered dose. Further observation indicated that the {99m}Tc-Al[2]O[3] accumulation reached a plateau in a lymph node (average 10.5%) during 2-hour study and then its accumulation remained practically at the same level, slightly increasing to 12% in 24 hours. In case of {99m}Tc-Nanocis inguinal lymph node was visualized in all animals for 15 min when it was accumulated on the average 1.03% of the administered dose. Plateau of {99m}Tc-Nanocis accumulation in the lymph node (average 2.05%) occurred after 2 hours of the study and remained almost on the same level (in average 2.3%) for 24 hours. Thus, the experimental study of a new domestic radiopharmaceutical showed that the {99m}Tc-Al[2]O[3]accumulates actively in the lymph nodes several times as compared to the imported analogue and its practical application will facilitate intraoperative identification of sentinel lymph nodes. |
URI: | http://earchive.tpu.ru/handle/11683/35772 |
Располагается в коллекциях: | Материалы конференций |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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dx.doi.org-10.1063-1.4960231.pdf | 281,47 kB | Adobe PDF | Просмотреть/Открыть |
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