Планирование нейтрон - захватной терапии с комплексами гадолиния по данным магнитно-резонансной томографии с парамагнитным контрастированием

Abstract

In the present study, we performed a method for quantitative analysis for estimate a content of the neutron-acceptors in tumor tissues for planning gadolinium NCT. The study was conducted with dynamic contrast-enhanced MRI with Gd-DTPA. The phantoms experiments showed the dependence of the MR signal intensity from the drug concentration in the tumor. To describe the absorption of Gd-DTPA in tumor a classical passive transport GRP model was used. We described the procedure of tumor blood flow measurement. It was proved that the blood flow value depends on the degree of tumor malignancy. The implementation of the described planning NСT method in clinical practice will allow to determine the onset of irradiation, to bring the maximum dose to therapeutic focus and carry out personalization of treatment in order to increase the effectiveness of NCT.