Экспрессия анти-апоптозного белка Bcl-xL в глутаматергических нейронах гиппокампа при их оптогенетической стимуляции

Abstract

The anti-apoptotic protein Bcl-xl takes part in processes of neuroplasticity such as synaptogenesis and release of neurotransmitters. In this study dependence of Bcl-xL expression on neuron activity was analyzed by in vivo optogenetic activating of the hippocampal glutamatergic neurons. The immunohistochemically determined level of protein Bcl-xL increased in photosensitive neurons as well as the level of the early response protein c- Fos that prove their activating by light. The activity-dependent expression of Bcl-xL support its role in neuroplasticity.