Цитогенетические нарушения в лимфоцитах крови у работников ядерного производства, подвергавшихся низкоинтенсивному радиационному воздействию

Abstract

The main aim of this study was to analyze the data on the frequency and spectrum of cytogenetic abnormalities in the cohort of Siberian Group of Chemical Enterprises (SGCE) employees, considering their age and sex, type of radiation and external irradiation dose. There were studied the samples obtained from 1 300 SGCE employees exposed. We have found that the dose dependence of quantity of aberrant cells, chromosome abnormalities, point fragments and dicentric chromosomes in SGCE workers is non-linear. In case of irradiation dose is to 10 mSv there has been observed the significant decreasing the number of aberrant cells, chromosome and chromatid abnormalities as compared with the control group, this corresponds to the phenomenon of the radiation hormesis. There has been observed significant rising of a quantity of aberrant metaphases and chromosome and chromatid abnormalities starting from dosage range of 40-100 mSv. In dosage range of 100-500 mSv the dose dependence has a plateau and the frequency of cytogenetic abnormalities is constant, but significance is increasing relatively the control group.