Роль генов TH BS1, WHSC1, ADAMTS1 и RBFOX2 в репарации радиационно индуцированных двунитевых разрывов ДНК в клетках опухолевой линии Hela

Abstract

It is well known that inter-individual differences of radiosensitivity have genetic causes, such as variations in the level of DNA or expression of DNA repair genes. However, differentially expressed genes which could lead to inter-individual differences in the level of DNA damage remain largely unidentified. In our study we have induced knock-out of THBS1, WHSC1, ADAMTS1 and RBFOX2 genes in HeLa cell line to clarify the effects of these genes on DNA repair and radiosensitivity.