Кариопатологически е изменения в клетках буккального эпителия у людей, страдающих заболеваниями в области оториноларингологии

Abstract

This work consisted in the study of karyopatologic changes in buccal epithelium of the people, who suffer different otolaryngologic diseases: chronic tonsillitis, acute nasopharyngitis, chronic vasomotor rhinitis and chronic rhinosinusitis. The results of the karyopatologic study in buccal epithelium of the patients with ENT diseases were compared with the corresponding figures of the control group of people who do not suffer these diseases. The experimental and control group consisted of 10 persons. No less than 1000 buccal epithelium cells were analyzed with every drug, made by pap smear. The buccal epitheliocytus comparative analysis of the healthy people and people who suffer otolaryngologic diseases showed the significant rise of cells with karyolysis in epithelium of the diseased(38,8±7,5 versus 7,4±1,2% in control, at p<0,01)and with karyopyknosis (2,8±0,4 versus 1,6±0,4% in control, at p>0,05). Frequency of other karyopatologies: karyorhexis of cells with binuclear kernels with microkernels did not have statistically significant differences with control level. Both processes: karyolysis and karyopyknosis are different types of sell apoptosis which is one of the mechanisms to remove genetically defected cells from organism. The same changes (karyolysis) were registered in the studies of other scientists dedicated to the patients suffered chronic vasomotor rhinitis, chronic rhinosinusitis and acute nasopharyngitis.