Исследование ассоциаций полиморфных вариантов генов системы цитохромов Р-450 и гена белка множественной лекарственной устойчивости с развитием лекарственно-индуцированной гиперпролактинемии при шизофрении

Abstract

The detection of clinical and biological associations in different alleles and genotypes allows to create the fundament for development methods, which help to identify risk of side-effects in patients with schizophrenia, who received long-term antipsychotics treatment. The aim of this study was to analyze the role of polymorphic variants of genes cytochrome P-450 system and multi-drug resistance gene (MDR1) in pathogenesis of druginduced hyperprolactinemia in schizophrenia patients. In our research were detected statistically significant associations between polymorphic variants of multi-drug resistance gene and hyperprolactinemia which suggest this gene involvement in pathogenesis of this side-effect.