Валида ция связи генного полиморфизма с повышенной частотой хромосомных аберраций у работников радиационного производства

Abstract

The results from the research into the association between polymorphisms of genes-candidates for individual radiosensitivity and the frequency and spectrum of cytogenetic abnormalities are analyzed. These polymorphisms have been previously identified in our microarray studies using “Cancer_SNP_Panel GT-17- 211” (“Illumina”, USA) in 2013. The study was conducted among Siberian Group of Chemical Enterprises healthy employees (n = 158) exposed to professional irradiation in a dose range of 100-300 mSv. We have found that 16 SNPs are associated with the frequency of dicentric and ring (the radiation exposure markers). We have found that 9 SNPs are confirmed to be associated with the frequency of dicentric (INSR rs1051690, TNKS rs33945943, CYP24A1 rs751087, GSK3B rs4624596, GSK3B rs4688046, GSK3B rs10934500, GSK3B rs1574154, GSK3B rs2873950, VCAM1 rs2392221) and 14 SNPs are confirmed to be associated with the frequency of ring (ESR1 rs488133, PIN1 rs889162, PIN1 rs2233679, CYP2С19 rs4986894, CYP24A1 rs751087, APAF1 rs2288729, MPDU1 rs4227, GSK3B rs4624596, GSK3B rs4688046, GSK3B rs10934500, GSK3B rs10934503, GSK3B rs1574154, GSK3B rs2873950, VCAM1 rs2392221).