Изучение ассоциации генов IL10 (RS1800872) и TNFα (RS2239704) с развитием туберкулеза легких

Abstract

Tuberculosis (TB) is the most dangerous widespread infectious disease in the world caused by Mycobacteria tuberculosis. Genetic factors are important in the development of TB. Defense against TB infection is provided through T- cell host immunity. Resistance to Mycobacteria tuberculosis is determined by T helper type 1 (Th1) cells and their cytokines. Cytokine spectrum of Th-1 is represented by proinflammatory cytokines: interferon gamma (IFN γ), interleukin-12, interleukin-2 and tumor necrosis factor alpha (TNFα). On the other hand Th-2 response characterized by the secretion of cytokines (interleukin-4 and interleukin-10) is associated with the lack of protection in TB. Thus Th-1/Th-2 balance is very important for definition the outcome of infection disease. In this study we take into account of genetic polymorphisms IL10 (rs1800872) and TNFα (rs2239704) in TB patients and healthy individuals. Results of genotyping and statistical comparison have shown a strong significance association of IL10 and TNFα with susceptibility to pulmonary TB in Tomsk population.