Влияние экстракта плодов аронии черноплодной (Aronia melanocarpa (michx.) Elliot) на эритроидный росток кроветворения в условиях цитостатического воздействия

Abstract

This study researches the effect of the black chokeberry fruit extract (Aronia melanocarpa (michx.) Elliot) on the the hematopoietic erythroid lineage under conditions of the cytostatic effect. The study is important today because oncological patients undergoing cytostatic chemotherapy have noticeable suppression of the hematopoietic erythroid lineage, and, as a result, the development of anemic syndrome. Yet there are few ways of correcting the anemic syndrome. The aim of this work is to study the effect of the black chokeberry fruit extract (Aronia melanocarpa (michx.) Elliot) on the the hematopoietic erythroid lineage under conditions of the cytostatic effect. The suppressed model of the hematopoietic erythroid lineage was cytostatic myelosuppression induced by a single [acute] dosing of doxorubicin to healthy mice intraperitoneally at the maximum tolerated dose (6 mg/kg). The experiments were performed on 78 female C57BL/6 mice, the black chokeberry fruit extract (Aronia melanocarpa (michx.) Elliot) was injected into the mice daily per os. at a dose of 5 ml/kg for 14 days, 24 hours after a single [acute] dose of doxorubicin. As expected, the injection of doxorubicin at the maximum tolerated dose leads to the evident suppression of the hematopoietic erythroid lineage. The course introduction of the black chokeberry fruit extract (Aronia melanocarpa (michx.) Elliot) had a stimulating effect on the processes of erythropoiesis under conditions of cytostatic myelosuppression.