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Title: | Модуляция окислительного стресса в антипаразитарной терапии инвазии Opisthorchis felineus |
Other Titles: | Modulation of oxidative stress in anti-parasitic therapy of Opisthorchis felineus infection |
Authors: | Перина, Е. А. Буйко, Е. Е. |
metadata.dc.contributor.advisor: | Иванов, В. В. |
Keywords: | модуляция; терапия; жизнеспособность; лечение; трематоды; паразиты; окислительный стресс |
Issue Date: | 2020 |
Publisher: | Изд-во ТУСУР |
Citation: | Перина Е. А. Модуляция окислительного стресса в антипаразитарной терапии инвазии Opisthorchis felineus / Е. А. Перина, Е. Е. Буйко ; науч. рук. В. В. Иванов // Перспективы развития фундаментальных наук : сборник научных трудов XVII Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 21-24 апреля 2020 г. : в 7 т. — Томск : Изд-во ТУСУР, 2020. — Т. 4 : Биология и фундаментальная медицина. — [67-69]. |
Abstract: | The influence of oxidative stress caused by L-butionine-sulfoximine and hydrogen peroxide on the O. felineus mature forms viability and egg production was determined. Oxidative stress induced by H[2]O[2] at 125 [mu]M and 250 [mu]M did not affect the viability of O. felineus mature forms. Also, it caused a decrease in egg production. After the pre-incubation of O. felineus mature forms with inhibitor of the main antioxidant enzyme (glutathione) synthesis L-butionine-sulfoximine, the hydrogen peroxide leads to the marit cells death at lower concentrations of prooxidant (0.125 and 0.250 mM H[2]O[2]).Thus, [gamma]-glutamylcysteineligase inhibition by L-butionine-sulfoximine leads to an increase in the O. felineus mature forms sensitivity to exogenous reactive oxygen species, which makes it possible to consider this key glutathione synthesis enzyme as a promising potential therapeutic target in the opisthorchiasis treatment. |
URI: | http://earchive.tpu.ru/handle/11683/63008 |
Appears in Collections: | Материалы конференций |
Files in This Item:
File | Description | Size | Format | |
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conference_tpu-2020-C21_V4_p67-69.pdf | 295,42 kB | Adobe PDF | View/Open |
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