Применение [beta]-циклодекстрина для грануляции во взвешенном слое

Abstract

In the present study, we investigated cyclodextrine as an excipient for tablet. In the pharmaceutical industry, the particulate ingredients are often granulated to improve their flowability and uniformity. A fluidized bed gas-solid drying is usually followed to remove the moisture that is introduced during the granulation. Fluidized bed granulation is a widely applied wet granulation technique in the pharmaceutical industry, exhibiting some technological advantages compared to the multistage wet granulation methods. Of the three available cyclodextrin forms, b-cyclodextrin is the most commonly used cyclodextrin in pharmaceutical formulations and the best studied cyclodextrin in humans. The possibility of using b-cyclodextrin in the production process of solid dosage forms using the technology of drying in a fluidized bed was confirmed.