Разработка методики изучения антимикробной активности прототипов твердых лекарственных форм с функцией контролируемого высвобождения антибиотиков

Abstract

Currently, there are many methods for testing the antibacterial activity of solid dosage forms intended for targeted delivery and controlled release of drugs. The standard diffusion method has a number of limitations, the main one of which is the impossibility of assessing the antibacterial activity of samples in vitro under conditions of skin damage. Infiltration method has been developed, which allows a deeper assessment of the antibacterial activity of solid dosage forms. As a result of a study on a polymer scaffold model, it was found that targeted delivery of chloramphenicol can potentially increase the growth inhibition of both S. aureus and E. coli, which will further reduce the systemic dose of drugs prescribed to patients.