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dc.contributor.authorLitvinova, L. S.en
dc.contributor.authorShupletsova, Valeriaen
dc.contributor.authorKhaziakhmatova, O. G.en
dc.contributor.authorDaminova, A. G.en
dc.contributor.authorKudryavtseva, V. L.en
dc.contributor.authorYurova, K. A.en
dc.contributor.authorMalashchenko, V. V.en
dc.contributor.authorTodosenko, Nataliaen
dc.contributor.authorPopova, Valentina Aleksandrovnaen
dc.contributor.authorLitvinov, R. I.en
dc.contributor.authorKorotkova, Elena Ivanovnaen
dc.contributor.authorSukhorukov, Gleben
dc.contributor.authorGow, Andrewen
dc.contributor.authorWeissman, D.en
dc.contributor.authorAtochina-Vasserman, E. N.en
dc.contributor.authorKhlusov, Igor Albertovichen
dc.date.accessioned2022-05-04T09:28:18Z-
dc.date.available2022-05-04T09:28:18Z-
dc.date.issued2022-
dc.identifier.citationHuman Mesenchymal Stem Cells as a Carrier for a Cell-Mediated Drug Delivery / L. S. Litvinova, V. V. Shupletsova, O. G. Khaziakhmatova [et al.] // Frontiers in Bioengineering and Biotechnology. — 2022. — Vol. 10. — [796111, 14 p.].en
dc.identifier.urihttp://earchive.tpu.ru/handle/11683/70707-
dc.description.abstractA number of preclinical and clinical studies have demonstrated the efficiency of mesenchymal stromal cells to serve as an excellent base for a cell-mediated drug delivery system. Cell-based targeted drug delivery has received much attention as a system to facilitate the uptake a nd transfer of active substances to specific organs and tissues with high efficiency. Human mesenchymal stem cells (MSCs) are attracting increased interest as a promising tool for cell-based therapy due to their high proliferative capacity, multi-potency, and anti-inflammatory and immunomodulatory properties. In particular, these cells are potentially suitable for use as encapsulated drug transporters to sites of inflammation. Here, we studied the in vitro effects of incorporating synthetic polymer microcapsules at various microcapsule-to-cell ratios on the morphology, ultrastructure, cytokine profile, and migration ability of human adipose-derived MSCs at various time points post-phagocytosis. The data show that under appropriate conditions, human MSCs can be efficiently loaded with synthesized microcapsules without damaging the cell’s structural integrity with unexpressed cytokine secretion, retained motility, and ability to migrate through 8 ?m pores. Thus, the strategy of using human MSCs as a delivery vehicle for transferring microcapsules, containing bioactive material, across the tissue–blood or tumor–blood barriers to facilitate the treatment of stroke, cancer, or inflammatory diseases may open a new therapeutic perspective.en
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.publisherFrontiers Media S. A.en
dc.relation.ispartofFrontiers in Bioengineering and Biotechnology. 2022. Vol. 10en
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/-
dc.sourceFrontiers in Bioengineering and Biotechnologyen
dc.subjectстволовые клеткиru
dc.subjectжировые тканиru
dc.subjectклеточная миграцияru
dc.subjectадресная доставкаru
dc.subjectмикрокапсулыru
dc.subjectлекарстваru
dc.subjecthuman adipose-derived mesenchymal stromal/stem cellsen
dc.subjectcell migrationen
dc.subjecttarget drug deliveryen
dc.subjectcellmediated drug deliveryen
dc.subjectsynthetic microcapsulesen
dc.titleHuman Mesenchymal Stem Cells as a Carrier for a Cell-Mediated Drug Deliveryen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dcterms.audienceResearchesen
local.description.firstpage796111-
local.filepathreprint-nw-38741.pdf-
local.filepathhttps://doi.org/10.3389/fbioe.2022.796111-
local.identifier.bibrecRU\TPU\network\38741-
local.identifier.perskeyRU\TPU\pers\46100-
local.identifier.perskeyRU\TPU\pers\31278-
local.identifier.perskeyRU\TPU\pers\34907-
local.localtypeСтатьяru
local.volume10-
dc.identifier.doi10.3389/fbioe.2022.796111-
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