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dc.contributor.authorDemin, Alexanderen
dc.contributor.authorVakhrushev, Aleksandren
dc.contributor.authorPershina, Aleksandra Gennadievnaen
dc.contributor.authorValova, Marinaen
dc.contributor.authorEfimova, Lina Viktorovnaen
dc.contributor.authorSemchina, Aleksandraen
dc.contributor.authorUymin, Mikhail Aleksandrovichen
dc.contributor.authorMinin, Artem Sergeevichen
dc.contributor.authorLevit, Galinaen
dc.contributor.authorKrasnov, Viktoren
dc.contributor.authorCharushin, Valeryen
dc.date.accessioned2023-03-28T09:20:17Z-
dc.date.available2023-03-28T09:20:17Z-
dc.date.issued2022-
dc.identifier.citationMagnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines / A. M. Demin, A. V. Vakhrushev, A. G. Pershina [et al.] // International Journal of Molecular Sciences. — 2022. — Vol. 23, iss. 16. — [9093, 14 p. ].en
dc.identifier.urihttp://earchive.tpu.ru/handle/11683/74887-
dc.description.abstractNovel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.en
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.ispartofInternational Journal of Molecular Sciences. 2022. Vol. 23, iss. 16en
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/-
dc.sourceInternational Journal of Molecular Sciencesen
dc.subjectмагнитные наночастицыru
dc.subjectдоксорубицинru
dc.subjectпеременное магнитное полеru
dc.subjectопухолевые клеткиru
dc.subjectдоставкаru
dc.subjectлекарстваru
dc.subjectmagnetic nanoparticlesen
dc.subjectSiO2en
dc.subjectPEGen
dc.subjectdoxorubicinen
dc.subjectalternating magnetic fielden
dc.subjecttumor cellsen
dc.subjectdrug-deliveryen
dc.titleMagnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Linesen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dcterms.audienceResearchesen
local.description.firstpage9093-
local.filepathreprint-nw-40024.pdf-
local.filepathhttps://doi.org/10.3390/ijms23169093-
local.identifier.bibrecRU\TPU\network\40024-
local.identifier.perskeyRU\TPU\pers\32466-
local.issue16-
local.localtypeСтатьяru
local.volume23-
dc.identifier.doi10.3390/ijms23169093-
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