Разработка метода модификации наночастиц ноль валентного железа для применения в биомедицинской области

Abstract

New and easy approach for in situ synthesis of zerovalent magnetic aryl coated iron NPs was proposed. Arenediazonium tosylates were used as modification agent to give long term protection to the highly reactive zerovalent iron core. Obtained NPs with average particle size of 10 nm are highly stable and are not expose to the air oxidation. Advantages of the present methodology rely not only on the rapidity, efficiency, mild condition of synthesis and low price of precursor but also on the formation of strong covalent binding, this features make obtained NPs highly suitable for further medical applications. Stabilized suspension of obtained NPs can be also used for development of imaging contrast agent for MRI analysis, or even as theranostic agent.