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http://earchive.tpu.ru/handle/11683/132443| Title: | Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation |
| Authors: | Popov, Alexander Suvorov, Nikita Larkina, Mariya Sergeevna Plotnikov, Evgeny Vladimirovich Varvashenya, Ruslan Nikolaevich Bodenko, Vitalina Vasiljevna Yanovich, Gleb Ostroverkhov, Petr Usachev, Maxim Filonenko, Elena Belousov, Mikhail Valerjevich Grin, Mikhail |
| Keywords: | technetium-99m; chlorin; radiopharmaceuticals; HYNIC; cancer |
| Issue Date: | 2025 |
| Publisher: | MDPI AG |
| Citation: | Novel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation / Alexander Popov, Nikita Suvorov, Mariia Larkina [et al.] // Molecules. — 2025. — Vol. 30, iss. 1. — Article number 117, 17 p.. |
| Abstract: | The use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides, 99mTc is a promising isotope that has been used to create several drugs for clinical use. One of the most effective 99mTc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues. At the same time, it is known that tetrapyrrole macrocycles are capable of selective accumulation in tumors, and thus can be used to target radiopharmaceuticals with 99mTc. In this work, the conjugate of natural chlorin and HYNIC was obtained, and preliminary preclinical studies were carried out on its radiocomplex with 99mTc |
| URI: | http://earchive.tpu.ru/handle/11683/132443 |
| Appears in Collections: | Репринты научных публикаций |
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| reprint-679724.pdf | 1,54 MB | Adobe PDF | View/Open |
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