Please use this identifier to cite or link to this item: http://earchive.tpu.ru/handle/11683/50915
Title: Гормоны стресса: кортизол, адренокортикотропный гормон и окситоцин в контексте социальных нарушений детей с расстройствами аутистического спектра
Other Titles: Stress hormones: cortisol, adrenocorticotropic hormone and oxytocin in the context of social violations in children with autism spectrum disorders
Authors: Тимофеева, А. В.
Филиппова, Ю. Ю.
metadata.dc.contributor.advisor: Бурмистрова, А. Л.
Keywords: гормоны; стрессы; нарушения; аутизм; дети
Issue Date: 2018
Publisher: Издательский Дом Томского государственного университета
Citation: Тимофеева А. В. Гормоны стресса: кортизол, адренокортикотропный гормон и окситоцин в контексте социальных нарушений детей с расстройствами аутистического спектра / А. В. Тимофеева, Ю. Ю. Филиппова ; науч. рук. А. Л. Бурмистрова // Перспективы развития фундаментальных наук : сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 24-27 апреля 2018 г. : в 7 т. — Томск : Издательский Дом Томского государственного университета, 2018. — Т. 4 : Биология и фундаментальная медицина. — [С. 146-148].
Abstract: Autism spectrum disorders (ASD) refer to heterogeneous disorders of neurodevelopment, the main symptom of which is social insufficiency. Aim: to conduct a one-stage assessment of the relationship between key hormones in the regulation of social and stress responses: adrenocorticotropic hormone (ACTH), cortisol, oxytocin, in children with ASD in the context of severe social insufficiency. Materials and methods. A total of 44 children (37 boys and 7 girls) aged 3 to 12 years with a diagnosis of ASD were examined, which were divided into groups: with preserved social contact / lack of it. The concentrations of hormones were evaluated in blood plasma by the method of ELISA. Results. ACTH and cortisol demonstrate interdependent relationships without the involvement of oxytocin in children with ASD, while maintaining their social contact. In children with ASD with symptoms of social insufficiency, there are no correlations between the studied neurohormones. The conclusion. The data obtained suggest that the processes of disorganization / destruction of neuroanatomical and physiological connections between the systems of oxytocin and the hypothalamic-pituitary-adrenal axis (HPA-axis) and (or) the hypothalamic-neurohypophysis system and the HPA-axis.
URI: http://earchive.tpu.ru/handle/11683/50915
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