Влияние курсового введения пентоксифиллина на гемодинамику, реологические свойства крови и вазодилататорную активность эндотелия у крыс SHR в период развития артериальной гипертензии

Abstract

The present study was aimed to investigate the effect of pentoxifylline (PTX) administration on arterial pressure, rheological parameters of blood, and endothelial function in SHRs during the development of arterial hypertension. SHRs were treated intragastrically with PTX at a dose of 100 mg/kg for 6 weeks. It was shown that administration of PTX limited the blood pressure increase and attenuated the severity of hyperviscosity syndrome in hypertensive animals.