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http://earchive.tpu.ru/handle/11683/74887| Title: | Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines |
| Authors: | Demin, Alexander Vakhrushev, Aleksandr Pershina, Aleksandra Gennadievna Valova, Marina Efimova, Lina Viktorovna Semchina, Aleksandra Uymin, Mikhail Aleksandrovich Minin, Artem Sergeevich Levit, Galina Krasnov, Viktor Charushin, Valery |
| Keywords: | магнитные наночастицы; доксорубицин; переменное магнитное поле; опухолевые клетки; доставка; лекарства; magnetic nanoparticles; SiO2; PEG; doxorubicin; alternating magnetic field; tumor cells; drug-delivery |
| Issue Date: | 2022 |
| Publisher: | MDPI AG |
| Citation: | Magnetic-Responsive Doxorubicin-Containing Materials Based on Fe3O4 Nanoparticles with a SiO2/PEG Shell and Study of Their Effects on Cancer Cell Lines / A. M. Demin, A. V. Vakhrushev, A. G. Pershina [et al.] // International Journal of Molecular Sciences. — 2022. — Vol. 23, iss. 16. — [9093, 14 p. ]. |
| Abstract: | Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid–polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated. |
| URI: | http://earchive.tpu.ru/handle/11683/74887 |
| Appears in Collections: | Репринты научных публикаций |
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|---|---|---|---|---|
| reprint-nw-40024.pdf | 2,72 MB | Adobe PDF | View/Open |
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