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dc.contributor.authorPopov, Alexanderen
dc.contributor.authorSuvorov, Nikitaen
dc.contributor.authorLarkina, Mariya Sergeevnaen
dc.contributor.authorPlotnikov, Evgeny Vladimirovichen
dc.contributor.authorVarvashenya, Ruslan Nikolaevichen
dc.contributor.authorBodenko, Vitalina Vasiljevnaen
dc.contributor.authorYanovich, Gleben
dc.contributor.authorOstroverkhov, Petren
dc.contributor.authorUsachev, Maximen
dc.contributor.authorFilonenko, Elenaen
dc.contributor.authorBelousov, Mikhail Valerjevichen
dc.contributor.authorGrin, Mikhailen
dc.date.accessioned2025-09-08T08:07:26Z-
dc.date.available2025-09-08T08:07:26Z-
dc.date.issued2025-
dc.identifier.citationNovel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluation / Alexander Popov, Nikita Suvorov, Mariia Larkina [et al.] // Molecules. — 2025. — Vol. 30, iss. 1. — Article number 117, 17 p..en
dc.identifier.urihttp://earchive.tpu.ru/handle/11683/132443-
dc.description.abstractThe use of radiopharmaceuticals for diagnostics in oncology allows for the detection of the disease at an early stage. Among diagnostic radionuclides, 99mTc is a promising isotope that has been used to create several drugs for clinical use. One of the most effective 99mTc chelators is 6-hydrazinylnicotinic acid (HYNIC), which, when combined with various vector molecules, can be used for targeted delivery of radionuclides to tumor tissues. At the same time, it is known that tetrapyrrole macrocycles are capable of selective accumulation in tumors, and thus can be used to target radiopharmaceuticals with 99mTc. In this work, the conjugate of natural chlorin and HYNIC was obtained, and preliminary preclinical studies were carried out on its radiocomplex with 99mTcen
dc.format.mimetypeapplication/pdf-
dc.language.isoenen
dc.publisherMDPI AGen
dc.relation.ispartofMolecules. 2025. Vol. 30, iss. 1en
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/-
dc.sourceMoleculesen
dc.subjecttechnetium-99men
dc.subjectchlorinen
dc.subjectradiopharmaceuticalsen
dc.subjectHYNICen
dc.subjectcanceren
dc.titleNovel Chlorin with a HYNIC: Synthesis, 99mTc-Radiolabeling, and Initial Preclinical Evaluationen
dc.typeArticleen
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dcterms.audienceResearchesen
local.filepathreprint-679724.pdf-
local.filepathhttps://doi.org/10.3390/molecules30010117-
local.identifier.bibrec(RuTPU)679724-
local.issue1-
local.localtypeСтатьяru
local.volume30-
dc.identifier.doi10.3390/molecules30010117-
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