Иммобилизация гиалуроновой кислоты на plla скаффолдах, обработанных плазмой атмосферного давления

Abstract

The effect of atmospheric pressure plasma treatment on properties of polylactic acid (PLLA) scaffoldsafter saturation in hyaluronic acid was investigated. Modification of scaffolds was performed in the system forthe formation of self-sustained volume discharge with following parameters: pulse repetition frequency - 500 Hz,pulse voltage - 20 kV, pulse duration - 120 ns, pulse energy - 0.3 J. Properties of the scaffolds were examined bymeans of wettability analysis, 1H NMR analysis and scanning electron microscopy. It was shown that treatmentof scaffolds does not change surface morphology, significantly increasing hydrophilicity of scaffolds and allowsimmobilizing of hyaluronic acid on the surface due to intensive formation of free radicals on the surface.