Связь хитиназо -подобных белков с метастазированием у больных раком молочной железы

Abstract

In the present study, we performed the analysis of chitinase-like protein expression in specimens from patients with breast cancer. It was found that a higher risk of lymphogenous and hematogenous metastasis in patients with breast cancer was associated with a low level of YKL39 gene expression. We supposed that different variants of parenchymal-stromal-inflammatory relationship in tissue can determine the nature of lymphogenous and hematogenous metastasis, as well as the tumor response to chemotherapy. These processes are realized through the functional interrelation of cells of the inflammatory infiltrate and other components of tumor microenvironment with cells of the tumor itself.