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Title: | Широкогеномное иссл едование прогностической значимости явления потери гетерозиготности в опухолевой ткани молочной железы |
Other Titles: | Genomic approach in the research prognostic significance of effects loss of heterozygosity in tumor tissue breast |
Authors: | Цыганов, М. М. Дерюшева, И. В. Ибрагимова, М. К. |
metadata.dc.contributor.advisor: | Литвяков, Н. В. |
Keywords: | полиморфизм; генотип; ДНК; молочные железы; онкология; опухоли |
Issue Date: | 2017 |
Publisher: | Изд-во ТПУ |
Citation: | Цыганов М. М. Широкогеномное иссл едование прогностической значимости явления потери гетерозиготности в опухолевой ткани молочной железы / М. М. Цыганов, И. В. Дерюшева, М. К. Ибрагимова ; науч. рук. Н. В. Литвяков // Перспективы развития фундаментальных наук : сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г. : в 7 т. — Томск : Изд-во ТПУ, 2017. — Т. 4 : Биология и фундаментальная медицина. — [С. 175-177]. |
Abstract: | One of the variability factors of malignant tumors, particularly breast cancer is a genetic variation due to gene polymorphism, and especially - the phenomenon of loss of heterozygosity (LOH). It has been shown that LOH in some genes could be a good prognostic marker. Thus, the aim of this work was genome-wide association study of loss of heterozygosity and Metastasis-free survival in breast cancer. The study involved 68 patients with breast cancer. To evaluate LOH status that was conducted by microarray analysis on high density DNA-chips made by firm Affymetrix CytoScanTM HD Array. 13 815 genes were evaluated in order to reveal loss of heterozygosity. The frequency of LOH varied from 0% to 63%. As a result of the associative analysis four genes EDA2R, PGK1, TAF9B and CYSLTR1 were determined, the presence of loss of heterozygosity that was associated with Metastasis-free survival. The presence of LOH in these genes is associated with low Metastasisfree survival. |
URI: | http://earchive.tpu.ru/handle/11683/44892 |
Appears in Collections: | Материалы конференций |
Files in This Item:
File | Description | Size | Format | |
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conference_tpu-2017-C21_V4_p175-177.pdf | 457,89 kB | Adobe PDF | View/Open |
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