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http://earchive.tpu.ru/handle/11683/65323
Title: | 99mTc-labeled monosaccharide kits: development methods and quality control |
Authors: | Stasyuk (Stasiuk), Elena Sergeyevna Skuridin, Viktor Sergeyevich Rogov, Alexander Sergeyevich Zelchan, Roman Vladimirovich Sadkin, Vladimir Leonidovich Varlamova, Natalya Valeryevna Nesterov, Evgeny Alexandrovich |
Keywords: | визуализация; рак; разработка; лекарства; cancer imaging; drug development |
Issue Date: | 2020 |
Publisher: | Springer Nature |
Citation: | 99mTc-labeled monosaccharide kits: development methods and quality control / E. S. Stasyuk (Stasiuk), V. S. Skuridin, A. S. Rogov [et al.] // Scientific Reports. — 2020. — Vol. 10. — [5121, 9 p.]. |
Abstract: | The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma. |
URI: | http://earchive.tpu.ru/handle/11683/65323 |
Appears in Collections: | Репринты научных публикаций |
Files in This Item:
File | Description | Size | Format | |
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reprint-nw-33138.pdf | 1,15 MB | Adobe PDF | View/Open |
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