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Title: Дифениловый эфир как перспективный предшественник синтетических аналогов интерлейкина-4
Other Titles: Diphenyl ether as prospective interleukin-4 synthetic analogs' precursor
Authors: Катаева, В. А.
Станкевич, Ксения Сергеевна
metadata.dc.contributor.advisor: Филимонов, Виктор Дмитриевич
Keywords: синтез; гуанидин; спектроскопия; валентные колебания; карбоксилаты
Issue Date: 2017
Publisher: Изд-во ТПУ
Citation: Катаева В. А. Дифениловый эфир как перспективный предшественник синтетических аналогов интерлейкина-4 / В. А. Катаева, К. С. Станкевич ; науч. рук. В. Д. Филимонов // Перспективы развития фундаментальных наук : сборник научных трудов XIV Международной конференции студентов, аспирантов и молодых ученых, г. Томск, 25-28 апреля 2017 г. : в 7 т. — Томск : Изд-во ТПУ, 2017. — Т. 2 : Химия. — [С. 175-177].
Abstract: Interleukin-4 (IL-4) is a multifunctional cytokine secreted by a number of cells. IL-4 drives Th2- mediated allergy response; its overproduction leads to the development of atopic diseases. On the other hand, M2-like macrophages generated in the presence of IL-4 are responsible for the anti-inflammatory response and wound healing. Thus, both inhibition and stimulation of IL-4 secretion could be promising in the disease therapy. As a result of in silico similar analogs design, we found lead compounds that interact efficiently with the main amino acids on the surface of the IL-4 α-subunit (according to the calculations). The designed compounds have a potential to be applied as IL-4 inhibitors for treatment of diseases or IL-4 stimulators for immunoinformative smart biomaterials production. It was shown that asymmetrically substituted diphenyl ether is one of the promising scaffolds for the functionalization.
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