Дифениловый эфир как перспективный предшественник синтетических аналогов интерлейкина-4

Abstract

Interleukin-4 (IL-4) is a multifunctional cytokine secreted by a number of cells. IL-4 drives Th2- mediated allergy response; its overproduction leads to the development of atopic diseases. On the other hand, M2-like macrophages generated in the presence of IL-4 are responsible for the anti-inflammatory response and wound healing. Thus, both inhibition and stimulation of IL-4 secretion could be promising in the disease therapy. As a result of in silico similar analogs design, we found lead compounds that interact efficiently with the main amino acids on the surface of the IL-4 α-subunit (according to the calculations). The designed compounds have a potential to be applied as IL-4 inhibitors for treatment of diseases or IL-4 stimulators for immunoinformative smart biomaterials production. It was shown that asymmetrically substituted diphenyl ether is one of the promising scaffolds for the functionalization.