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Title: The Foundations of the Development of Technologies of the Synthesis of Radiopharmaceuticals
Authors: Larkina, M.
Podrezova, Ekaterina Vladimirovna
Bragina, O.
Stasyuk, Elena Sergeyevna
Yusubov, Mekhman Suleiman-Ogly (Suleimanovich)
Chernov, Vladimir Ivanovich
Zelchan, Roman Vladimirovich
Skuridin, Viktor Sergeyevich
Belousov, M.
Deev, Sergey Mikhaylovich
Keywords: синтез; радиофармпрепараты; мишени; ядерная медицина; радионуклиды; терапия
Issue Date: 2017
Publisher: AIP Publishing
Citation: The Foundations of the Development of Technologies of the Synthesis of Radiopharmaceuticals / M. Larkina [et al.] // AIP Conference Proceedings. — 2017. — Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17) : Proceedings of the International conference, 23–26 May 2017, Tomsk, Russia. — [020043, 3 p.].
Abstract: The selection of precursors (for example chelating agents) and development of a technique of chemical modification of the target molecules retaining its ability to bind to specific receptors are very important in the synthesis of radiopharmaceuticals. As some important precursors for target radiopharmaceuticals omega-iodo-aliphatic carboxylic acids and their esters can be used. We have developed an environmentally safe process for producing omega-iodoaliphatic carboxylic acids and their esters of the available, inexpensive and low toxic aliphatic cyclic ketones. We proposed a new method for the synthesis of the chelating agents omega-thia- or (bis(2-hydroxyethyl)amino)- aliphatic carboxylic acids (chelate 1 and chelate 2), which was caused by the existing disadvantages in the existing methods. Thus, based on our method the precursors (chelates) with yield of over 70-90% on the final stage were synthesized, and then the high effectiveness in producing target radiopharmaceuticals using different biomolecules was showed. 99mTc-chelates complexes were prepared with radiochemical purity >91% and found to be stable at room temperature for six hours.
Appears in Collections:Материалы конференций

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