Please use this identifier to cite or link to this item: http://earchive.tpu.ru/handle/11683/46886
Title: Clinical Significance of Sentinel Lymph Node Detection in Patients with Invasive Cervical Cancer
Authors: Sinilkin, Ivan Gennadjevich
Chernov, Vladimir Ivanovich
Lyapunov, A. Yu.
Medvedeva, Anna Aleksndrovna
Zeltchan, R. V.
Chernyshova, A. L.
Kolomiets, L. A.
Bragina, Olga Dmitrievna
Keywords: обнаружение; лимфатические узлы; рак; компьютерная томография; репродуктивные органы; опухоли; выживаемость; женские болезни
Issue Date: 2017
Publisher: AIP Publishing
Citation: Clinical Significance of Sentinel Lymph Node Detection in Patients with Invasive Cervical Cancer / I. G. Sinilkin [et al.] // AIP Conference Proceedings. — 2017. — Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17) : Proceedings of the International conference, 23–26 May 2017, Tomsk, Russia. — [020069, 4 p.].
Abstract: The clinical significance of determining sentinel lymph nodes (SLN) in patients with invasive cervical cancer was studied. From 2013 to 2014, 30 cervical cancer patients (T1a1NxM0-T1b1NxM0) were treated at the Gynecological Oncology Department of the Cancer Research Institute. The day before surgery, four submucosal injections of 99mTc Al2O3 at a total dose of 80 MBq were made in each quadrant around the cervical tumor. Patients were submitted to preoperative lymphoscintigraphy and intraoperative SLN detection. The feasibility of preserving the reproductive potential in patients after radical abdominal trachelectomy was assessed. The 3-year, overall, disease-free and metastasis-free survival rates were analyzed. Thirty-four SLNs were detected by single-photon emission computed tomography (SPECT) and 42 SLNs were identified by intraoperative gamma probe. The sensitivity in detecting SLNs was 100% for intraoperative SLN identification and 80% for SPECT image. The reproductive potential was preserved in 86% of patients. The 3-year overall and metastases-free survival rates were 100%. Recurrence occurred in 8.6% of cases.
URI: http://earchive.tpu.ru/handle/11683/46886
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