Установление соотношения изомерных метильных производных гликолурила в зависимости от условий синтеза

Abstract

Different isomers of dimethylglicoluril are produced by synthesis from monomethylurea and glyoxal.Symmetric isomers have psychotropic activity and asymmetric isomers are hard-separable. Methods ofchromatographic separation and analysis were developed to provide control synthesis derived glycoluril. Thismethods allows establishing relation of fractions methylated derived glycoluril according to synthesis conditions. Inthe formic acid solution with the addition of sulfuric acid produced only asymmetric isomers. In other solutions produced mixture of isomers in different proportions.