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http://earchive.tpu.ru/handle/11683/46883
Название: | Nuclear Medicine Imaging of Locally Advanced Laryngeal and Hypopharyngeal Cancer |
Авторы: | Medvedeva, Anna Aleksndrovna Chernov, Vladimir Ivanovich Zeltchan, R. Sinilkin, Ivan Gennadjevich Bragina, Olga Dmitrievna Chijevskaya, S. Choynzonov, E. Goldberg, A. |
Ключевые слова: | ядерная медицина; визуализация; рак; гортань; диагностические возможности; выживаемость |
Дата публикации: | 2017 |
Издатель: | AIP Publishing |
Библиографическое описание: | Nuclear Medicine Imaging of Locally Advanced Laryngeal and Hypopharyngeal Cancer / А. А. Medvedeva [et al.] // AIP Conference Proceedings. — 2017. — Vol. 1882 : Physics of Cancer: Interdisciplinary Problems and Clinical Applications (PC IPCA’17) : Proceedings of the International conference, 23–26 May 2017, Tomsk, Russia. — [020048, 6 p.]. |
Аннотация: | The diagnostic capabilities of nuclear medicine imaging in the detection and assessment of the spread of laryngeal/hypopharyngeal cancer were studied. A total of 40 patients with histologically verified laryngeal and hypopharyngeal cancer and 20 patients with benign laryngeal lesions were included into the study. Submucosal injections of {99m}Tc-MIBI and {99m}Tc-Alotech were made around the tumor. Single photon emission computed tomography (SPECT) was performed 20 minutes after the injection of {99m}Tc-MIBI. Sentinel lymph nodes (SLNs) were detected in 26 patients. In 18 hours after the injection of {99m}Tc-Alotech, SPECT was performed. In 24 hours after the injection of {99m}Tc-Alotech, intraoperative SLN detection was performed using Gamma Finder II. SPECT with {99m}Tc-MIBI revealed laryngeal and hypopharyngeal tumors in 38 of the 40 patients. The {99m}Tc-MIBI uptake in metastatic lymph nodes was visualized in 2 (17%) of the 12 patients. Twenty eight SLNs were detected by SPECT and 31 SLNs were identified using the intraoperative gamma probe. The percentage of {99m}Tc-Alotech in the SLN was 5-10% of the radioactivity in the injection site by SPECT and 18-33% by intraoperative gamma probe detection. Thus, SPECT with {99m}Tc-MIBI is an effective tool for the diagnosis of laryngeal/hypopharyngeal cancer. The sensitivity, specificity and accuracy of this technique were 95%, 80% and 92%, respectively. The use of {99m}Tc-Alotech for the detection of SLNs in patients with laryngeal/hypopharyngeal cancer is characterized by 92.8% sensitivity. |
URI: | http://earchive.tpu.ru/handle/11683/46883 |
Располагается в коллекциях: | Материалы конференций |
Файлы этого ресурса:
Файл | Описание | Размер | Формат | |
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doi.org-10.1063-1.5001627.pdf | 623,24 kB | Adobe PDF | Просмотреть/Открыть |
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