Влияние макрофагов на процесс деградации полимера

Abstract

Nowadays researches devoted to implantation are of great interest. The more attention is paid to methods of investigation of implants' biocompatibility and, in case of biodegradable implants, of lasting of degradation process. Both of these factors are determined with organism's immune response provided by the system of mononuclear phagocytes, starting from monocytes, and among them especially macrophages that rule the processes of inflammation and degradation of xenogenous material. Knowledge of macrophages' reaction on the object allows to evaluate the opportunities of using the material in living organisms and, for biodegradable implants, time of decomposition under in vivo conditions. The aim of the study was to investigate an influence of macrophages, stimulated in different ways, on the process of degradation of biodegradable polymer polylactide (pure and in composition with hydroxiapatite with 90 and 70 percent of polylactide, respectively) by examining the decrease of polymer's molecular weight. The result was supposed to show the dependence of molecular weight's decrease on different types of macrophages' stimulation.